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Npm2tm1Zuk
Targeted Allele Detail
Nomenclature
Symbol: Npm2tm1Zuk
Name: nucleophosmin/nucleoplasmin 2; targeted mutation 1, Martin M Matzuk
MGI ID: MGI:2182141
Synonyms: Npm2-
Gene: Npm2  Location: Chr14:70647302-70659244 bp, - strand  Genetic Position: Chr14, 36.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83658
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 (including the ATG initiation codon), exon 3 and the splice acceptor junction of exon 4 were replaced with a Pgk-HPRT expression cassette. Homozygous mutant ovaries lacked NPM2 protein as indicated by immunohistochemistry and Western blot analysis. (J:83658)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npm2 Mutation:  8 strains or lines available
References
Original:  J:83658 Burns KH, et al., Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science. 2003 Apr 25;300(5619):633-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory