Ctsg^tm1Ley
Targeted Allele Detail

Summary

• Symbol: Ctsg^tm1Ley
• Name: cathepsin G; targeted mutation 1, Timothy J Ley
• MGI ID: MGI:2182136
• Synonyms: Cathepsin G-, CG-
• Gene: Ctsg Location: Chr14:56337342-56340031 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Ctsg^tm1Ley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59006
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exon 3 and exon 4 were replaced with a neomycin selection cassette. The deleted region encodes amino acids 92 through 164. An absence of transcript and protein was determined in homozygous mutant mice via an S1 nuclease protection assay and Western blot analysis, both of bone marrow. Assays of extracts using a colorimetric peptide showed a lack of proteolytic activity in homozygous mutant mice. (J:59006)

Tumor Data

List all tumor models in MMHCdb carrying Ctsg^tm1Ley

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsg Mutation: 13 strains or lines available

References

• Original: J:59006 MacIvor DM, et al., Normal neutrophil function in cathepsin G-deficient mice. Blood. 1999 Dec 15;94(12):4282-93
• All: 25 reference(s)