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Targeted Allele Detail
Symbol: Ctsstm1Eae
Name: cathepsin S; targeted mutation 1, Eileen A Elliot
MGI ID: MGI:2182132
Synonyms: catS-
Gene: Ctss  Location: Chr3:95434097-95463714 bp, + strand  Genetic Position: Chr3, 40.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:53399
Parent Cell Line:  DBA-252 (ES Cell)
Strain of Origin:  DBA/1LacJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a 3.0kb region containing the active site residue. Functional ablation of the protein product in homozygous mutant mice was determined via an active-site labeling assay of splenocytes and LPS B cell blasts. (J:53399)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctss Mutation:  23 strains or lines available
The author (Renee LeBoeuf) has confirmed that the allele used in the reference J:153355 was incorrectly reported as Ctsstm1Hap; the correct allele is Ctsstm1Eae .
Original:  J:53399 Nakagawa TY, et al., Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity. 1999 Feb;10(2):207-17
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory