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Fgf9Eks
Spontaneous Allele Detail
Nomenclature
Symbol: Fgf9Eks
Name: fibroblast growth factor 9; elbow knee synostosis
MGI ID: MGI:2182127
Synonyms: Fgf9N143T
Gene: Fgf9  Location: Chr14:58308004-58350177 bp, + strand  Genetic Position: Chr14, 30.51 cM, cytoband D
Fgf9Eks/Fgf9Eks and Fgf9Eks/Fgf9+ mice display appendicular skeletal abnormalities

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J x DBA/2J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsAn A-to-C substitution at position 428 results in the amino acid substitution of asparagine with threonine at position 143 (p.N143T). This mutation is expected to affect homodimerization and receptor binding. (J:146802)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 28 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf9 Mutation:  14 strains or lines available
References
Original:  J:77537 Murakami H, et al., Elbow knee synostosis (Eks): a new mutation on mouse Chromosome 14. Mamm Genome. 2002 Jul;13(7):341-4
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory