Fgf9^Eks
Spontaneous Allele Detail

Summary

• Symbol: Fgf9^Eks
• Name: fibroblast growth factor 9; elbow knee synostosis
• MGI ID: MGI:2182127
• Synonyms: Fgf9^N143T
• Gene: Fgf9 Location: Chr14:58308004-58350177 bp, + strand Genetic Position: Chr14, 30.51 cM, cytoband D
• Alliance: Fgf9^Eks page

Fgf9^Eks/Fgf9^Eks and Fgf9^Eks/Fgf9⁺ mice display appendicular skeletal abnormalities

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J x DBA/2J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: An A-to-C substitution at position 428 results in the amino acid substitution of asparagine with threonine at position 143 (p.N143T). This mutation is expected to affect homodimerization and receptor binding. (J:146802)

Expression

In Structures Affected by this Mutation:

23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf9 Mutation: 15 strains or lines available

References

• Original: J:77537 Murakami H, et al., Elbow knee synostosis (Eks): a new mutation on mouse Chromosome 14. Mamm Genome. 2002 Jul;13(7):341-4
• All: 4 reference(s)