Pax4^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Pax4^tm1Pgr
• Name: paired box 4; targeted mutation 1, Peter Gruss
• MGI ID: MGI:2182122
• Synonyms: Pax4-
• Gene: Pax4 Location: Chr6:28442333-28449339 bp, - strand Genetic Position: Chr6, 11.99 cM
• Alliance: Pax4^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39208
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4, encoding the majority of the paired box domains, were replaced by a lacZ-neo fusion gene. The overall expression patterns of beta-galactosidase differed in heterozygous and homozygous mutant mice. (J:39208)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax4 Mutation: 26 strains or lines available

References

• Original: J:39208 Sosa-Pineda B, et al., The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature. 1997 Mar 27;386(6623):399-402
• All: 16 reference(s)