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Targeted Allele Detail
Symbol: Hlxtm1Rph
Name: H2.0-like homeobox; targeted mutation 1, Richard P Harvey
MGI ID: MGI:2182089
Synonyms: Hlx-
Gene: Hlx  Location: Chr1:184459340-184464690 bp, - strand  Genetic Position: Chr1, 88.97 cM
Hlxtm1Rph/Hlxtm1Rph mice at E17.5 are pale, reduced in size and exhibit hydrops

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:31553
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced the sequence encoding the DNA-binding helix 3 of the homeodomain. (J:31553)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hlx Mutation:  24 strains or lines available
Original:  J:31553 Hentsch B, et al., Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut. Genes Dev. 1996 Jan 1;10(1):70-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory