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Lhcgrtm1Zmlei
Targeted Allele Detail
Nomenclature
Symbol: Lhcgrtm1Zmlei
Name: luteinizing hormone/choriogonadotropin receptor; targeted mutation 1, Zhenmin Lei
MGI ID: MGI:2181998
Synonyms: LH-, Lhcgrtm1Cvr, LHRKO
Gene: Lhcgr  Location: Chr17:89023909-89099418 bp, - strand  Genetic Position: Chr17, 58.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66817
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing promoter elements, multiple transcription start sites and most of exon 1 was replaced by a neomycin selection gene. RT-PCR analysis confirmed that no detectable transcript was present in gonads of homozygous mice. Immunostaining on ovary sections of homozygous mice confirmed that no protein was produced from this allele. (J:66817)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 23 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lhcgr Mutation:  27 strains or lines available
References
Original:  J:66817 Lei ZM, et al., Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol Endocrinol. 2001 Jan;15(1):184-200
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory