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Cebpbtm1Pfj
Targeted Allele Detail
Nomenclature
Symbol: Cebpbtm1Pfj
Name: CCAAT/enhancer binding protein (C/EBP), beta; targeted mutation 1, Peter F Johnson
MGI ID: MGI:2181982
Synonyms: C/EBPbeta-, C/EBP-Beta-
Gene: Cebpb  Location: Chr2:167688915-167690418 bp, + strand  Genetic Position: Chr2, 87.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43075
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a 1.2kb region encompassing the entire promoter and coding sequences. Western blot analysis of liver nuclear extracts showed an absence of normal protein in homozygous mutant mice. (J:43075)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpb Mutation:  11 strains or lines available
References
Original:  J:43075 Sterneck E, et al., An essential role for C/EBPbeta in female reproduction. Genes Dev. 1997 Sep 1;11(17):2153-62
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory