Cebpb^tm1Pfj
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1Pfj
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1, Peter F Johnson
• MGI ID: MGI:2181982
• Synonyms: C/EBPbeta^-, C/EBP-Beta^-
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1Pfj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43075
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 1.2kb region encompassing the entire promoter and coding sequences. Western blot analysis of liver nuclear extracts showed an absence of normal protein in homozygous mutant mice. (J:43075)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 23 strains or lines available

References

• Original: J:43075 Sterneck E, et al., An essential role for C/EBPbeta in female reproduction. Genes Dev. 1997 Sep 1;11(17):2153-62
• All: 39 reference(s)