Del(3Cd1d2-Cd1d1)1Crw
Targeted Allele Detail

Summary

• Symbol: Del(3Cd1d2-Cd1d1)1Crw
• Name: deletion, Chr 3, Chyung-Ru Wang 1
• MGI ID: MGI:2181950
• Synonyms: CD1-, CD1d^-, Cd1d1^-, Cd1d1/Cd1d2^tm1Crw, CD1d KO, CD1-KO
• Gene: Del(3Cd1d2-Cd1d1)1Crw Location: unknown Genetic Position: Chr3, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39749
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(3Cd1d2-Cd1d1)1Crw involves 2 genes/genome features (Cd1d2, Cd1d1) View all
• Mutation details: Cd1d1 and Cd1d2 are adjacent loci that are arranged tail-to-tail, enabling the deletion of exons 4 through 6 from both loci with the insertion of a single neomycin selection cassette. RT-PCR analysis showed an absence of transcript in all tissues tested from homozygous mutant mice. A lack of protein surface expression was determined by immunofluorescence of thymocytes and splenocytes from homozygous mutant animals. (J:39749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(3Cd1d2-Cd1d1)1Crw Mutation: 0 strains or lines available

References

• Original: J:39749 Chen YH, et al., Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity. 1997 Apr;6(4):459-67
• All: 78 reference(s)