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Gja4tm1Paul
Targeted Allele Detail
Nomenclature
Symbol: Gja4tm1Paul
Name: gap junction protein, alpha 4; targeted mutation 1, David L Paul
MGI ID: MGI:2181813
Synonyms: Cx37-
Gene: Gja4  Location: Chr4:127311421-127314039 bp, - strand  Genetic Position: Chr4, 61.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38247
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region except for the first 77 base pairs was replaced with a PGK-neo cassette. Immunostaining of homozygous mutant oocytes showed a lack of protein expression. (J:38247)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 39 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja4 Mutation:  2 strains or lines available
References
Original:  J:38247 Simon AM, et al., Female infertility in mice lacking connexin 37. Nature. 1997 Feb 6;385(6616):525-9
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory