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Lgals1tm1Rob
Targeted Allele Detail
Nomenclature
Symbol: Lgals1tm1Rob
Name: lectin, galactose binding, soluble 1; targeted mutation 1, Elizabeth J Robertson
MGI ID: MGI:2181809
Synonyms: gal-1-, gal1-, Lgals1-
Gene: Lgals1  Location: Chr15:78926725-78930465 bp, + strand  Genetic Position: Chr15, 37.7 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:16245
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, encoding the carbohydrate-binding domain, was replaced with a neomycin selection cassette. Western blot analysis and immunostaining of sections showed an absence of encoded protein in muscle tissue obtained from adult homozygous mutant mice. (J:16245)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Lgals1 Mutation:  13 strains or lines available
References
Original:  J:16245 Poirier F, et al., Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development. 1993 Dec;119(4):1229-36
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory