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Targeted Allele Detail
Symbol: Mesttm1Masu
Name: mesoderm specific transcript; targeted mutation 1, M Azim Surani
MGI ID: MGI:2181803
Synonyms: Mest+/-, Mesttm1Lef, Mesttm1Lef-pat
Gene: Mest  Location: Chr6:30723547-30748465 bp, + strand  Genetic Position: Chr6, 12.53 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:50170
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encompassing all of exons 3 through 8 and a portion of exon 9 was replaced with a cassette containing an IRES-lacZ-neo fusion gene. RT-PCR analysis of total embryonic RNA showed an absence of normal transcript in animals possessing a targeted paternal allele and a silenced wild-type maternal allele. Paternal transmission of this allele yielded a lacZ expression pattern similar to that of the endogenous gene. (J:50170)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mest Mutation:  13 strains or lines available
Original:  J:50170 Lefebvre L, et al., Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest [see comments]. Nat Genet. 1998 Oct;20(2):163-9
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory