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Targeted Allele Detail
Symbol: Nfatc1tm1Glm
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Laurie H Glimcher
MGI ID: MGI:2181762
Synonyms: NFATc1-
Gene: Nfatc1  Location: Chr18:80606205-80713071 bp, - strand  Genetic Position: Chr18, 53.66 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:78376
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encoding 19 amino acids (635-653) of the Rel-homology domain were replaced by a neomycin selection cassette. A frameshift mutation was introduced into the downstream sequence encoding amino acids 654 through 710. Western blot analysis showed the presence of truncated peptide in homozygous mutant mice. Electromobility shift assays showed a lack of DNA-binding activity. (J:46398, J:78376)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 32 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc1 Mutation:  25 strains or lines available
Original:  J:78376 Ranger AM, et al., Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan;8(1):125-34
All:  17 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory