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Egr1tm1Pch
Targeted Allele Detail
Nomenclature
Symbol: Egr1tm1Pch
Name: early growth response 1; targeted mutation 1, Patrick Charnay
MGI ID: MGI:2181755
Synonyms: Egr-1-LacZ), Krox-24-, Zif268-
Gene: Egr1  Location: Chr18:34861207-34864956 bp, + strand  Genetic Position: Chr18, 18.76 cM, cytoband C/D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45064
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA construct containing a promoterless lacZ gene adjoined to a neomycin selection gene was inserted 50 bp upstream of the translational start codon. The insertion introduced a frameshift mutation upstream of the DNA-binding domain. An absence of encoded mRNA and protein was determined by in situ hybridization and immunocytochemical analyses of homozygous mutant mice. (J:45064)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr1 Mutation:  6 strains or lines available
References
Original:  J:45064 Topilko P, et al., Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice. Mol Endocrinol. 1998 Jan;12(1):107-22
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory