L1camtm1Mtei
Targeted Allele Detail
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Symbol: |
L1camtm1Mtei |
Name: |
L1 cell adhesion molecule; targeted mutation 1, Ned Mantei |
MGI ID: |
MGI:2181735 |
Synonyms: |
L1- |
Gene: |
L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
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Alliance: |
L1camtm1Mtei page
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Germline Transmission: |
Earliest citation of germline transmission:
J:43838
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Parent Cell Line: |
GS1 (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Exon 8 was disrupted by the insertion of a construct containing adjacent thymidine kinase and neomycin resistance genes. Low levels of a truncated transcript were detected via Northern blot analysis of total RNA isolated from homozygous mutant brain tissue (data not shown). Western blot analysis of protein extracts from homozygous mutant brain tissue showed an absence of the four isoforms detected in extracts from normal brain tissue, though low levels of a 190kD aberrant transcript were detected.
(J:43838)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any L1cam Mutation: |
12 strains or lines available
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Original: |
J:43838 Dahme M, et al., Disruption of the mouse L1 gene leads to malformations of the nervous system. Nat Genet. 1997 Nov;17(3):346-9 |
All: |
24 reference(s) |
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