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Targeted Allele Detail
Symbol: Rom1tm1Mci
Name: rod outer segment membrane protein 1; targeted mutation 1, Roderick R McInnes
MGI ID: MGI:2181662
Synonyms: Rom1-
Gene: Rom1  Location: Chr19:8904755-8906720 bp, - strand  Genetic Position: Chr19, 6.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:61888
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced exon 1 and a 5' portion of exon 2. Western blot analysis of crude retinal extracts showed an absence of encoded protein in homozygous mutant mice. (J:61888)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rom1 Mutation:  6 strains or lines available
Original:  J:61888 Clarke G, et al., Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nat Genet. 2000 May;25(1):67-73
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory