Igf2r^tm2Arge
Targeted Allele Detail

Summary

• Symbol: Igf2r^tm2Arge
• Name: insulin-like growth factor 2 receptor; targeted mutation 2, Argiris Efstratiadis
• MGI ID: MGI:2181650
• Synonyms: Igf2r^m-, Igf2r^p-
• Gene: Igf2r Location: Chr17:12901293-12988551 bp, - strand Genetic Position: Chr17, 8.64 cM, cytoband A-C
• Alliance: Igf2r^tm2Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34584
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Codons 28 to 38 of exon 1 were replaced with a neomycin resistance cassette via homologous recombination. (J:34584)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2r Mutation: 98 strains or lines available

Notes

ES cell line = CCE-33 (129/Sv). This gene is paternally imprinted and expressed only when maternally inherited. Inheritance of the paternal allele in the heterozygous state is equivalent to wild type homozygous mice, whereas inheritance of the maternal allele in the heterogyzous state is equivalent to knock-out homozygous mice.

References

• Original: J:34584 Ludwig T, et al., Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol. 1996 Aug 1;177(2):517-35
• All: 4 reference(s)