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Tbpl1tm1Rgr
Targeted Allele Detail
Nomenclature
Symbol: Tbpl1tm1Rgr
Name: TATA box binding protein-like 1; targeted mutation 1, Robert G Roeder
MGI ID: MGI:2181639
Synonyms: Trf2-
Gene: Tbpl1  Location: Chr10:22703879-22731938 bp, - strand  Genetic Position: Chr10, 10.25 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69502
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette deleted exons 3 through 6, encoding approximately 80% of the core region of the protein. Northern blot analysis of total RNA, using a probe corresponding to the targeted region, showed an absence of transcript in the testes of homozygous mutant mice. (J:69502)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbpl1 Mutation:  7 strains or lines available
References
Original:  J:69502 Zhang D, et al., Spermiogenesis deficiency in mice lacking the Trf2 gene. Science. 2001 May 11;292(5519):1153-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory