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Hprttm1(cre)Mnn
Targeted Allele Detail
Nomenclature
Symbol: Hprttm1(cre)Mnn
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 1, Jeffrey R Mann
MGI ID: MGI:2181632
Synonyms: Hprt1tm1(cre)Mnn, hprt-cre, Hprtcre, Hprttm1(CAG.cre)MdCoh
Gene: Hprt  Location: ChrX:52988137-53021659 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75826
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn expression cassette in which a CMV enhancer and chicken beta-globin promoter driving Cre recombinase expression was inserted in reverse transcriptional orientation into exon 3 of the gene. A PGK-neomycin selection cassette was also inserted following the cre gene. Expression of Cre recombinase occurred at high levels in the female germline and fertilized eggs, and all offspring of heterozyous females display excision of reporter sequences. (J:75826)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: CAG     Summary of all recombinase alleles driven by CAG.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  1265 strains or lines available
References
Original:  J:75826 Tang SH, et al., A cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ. Genesis. 2002 Mar;32(3):199-202
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory