Ptger2^tm2Bhk
Targeted Allele Detail

Summary

• Symbol: Ptger2^tm2Bhk
• Name: prostaglandin E receptor 2 (subtype EP2); targeted mutation 2, Beverly H Koller
• MGI ID: MGI:2181614
• Synonyms: EP2-
• Gene: Ptger2 Location: Chr14:45225652-45241277 bp, + strand Genetic Position: Chr14, 22.68 cM
• Alliance: Ptger2^tm2Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55713
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the gene was replaced by a neomycin selection cassette. RT-PCR analysis showed an absence of transcript in the uteri of homozygous mutant mice. (J:55713)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger2 Mutation: 31 strains or lines available

References

• Original: J:55713 Tilley SL, et al., Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor [see comments]. J Clin Invest. 1999 Jun;103(11):1539-45
• All: 22 reference(s)