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Targeted Allele Detail
Symbol: Stat5btm1Hwd
Name: signal transducer and activator of transcription 5B; targeted mutation 1, Helen W Davey
MGI ID: MGI:2181592
Synonyms: STAT5b-, Stat5b KO
Gene: Stat5b  Location: Chr11:100671557-100741407 bp, - strand  Genetic Position: Chr11, 63.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:41784
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into codon 181 via homologous recombination. Absence of gene expression in liver, spleen, mammary gland, thymus, kidney, and skeletal muscle of homozygous mutant animals was demonstrated by Northern and Western blot analyses. (J:41784)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 311874 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat5b Mutation:  24 strains or lines available
Original:  J:41784 Udy GB, et al., Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7239-44
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory