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Rlbp1tm1Jsa
Targeted Allele Detail
Nomenclature
Symbol: Rlbp1tm1Jsa
Name: retinaldehyde binding protein 1; targeted mutation 1, John C Saari
MGI ID: MGI:2181491
Synonyms: Rlbp1-
Gene: Rlbp1  Location: Chr7:79374865-79387043 bp, - strand  Genetic Position: Chr7, 45.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68444
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 3 via homologous recombination. Absence of gene expression in retinas of homozygous mutant mice was demonstrated by immunohistochemistry and Western blot analysis. (J:68444)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rlbp1 Mutation:  6 strains or lines available
References
Original:  J:68444 Saari JC, et al., Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation. Neuron. 2001 Mar;29(3):739-48
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory