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Targeted Allele Detail
Symbol: Cnn1tm1Tkhi
Name: calponin 1; targeted mutation 1, Katsuhito Takahashi
MGI ID: MGI:2181445
Gene: Cnn1  Location: Chr9:22099221-22109221 bp, + strand  Genetic Position: Chr9, 8.3 cM, cytoband A2-A4
Germline Transmission:  Earliest citation of germline transmission: J:77112
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA gpt-neo cassette replaced exons 5 through 7, encoding the regulatory binding region, conserved tandem repeats, and a carboxyl-terminal domain specific to the basic Calponin. RT-PCR analysis of homozygous mutant embryos showed an absence of basic transcript in both healthy and healing bone tissue. Western blot analysis confirmed an absence of the basic protein in homozygous mutant mice. (J:77112)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnn1 Mutation:  7 strains or lines available
Original:  J:77112 Yoshikawa H, et al., Mice lacking smooth muscle calponin display increased bone formation that is associated with enhancement of bone morphogenetic protein responses. Genes Cells. 1998 Oct;3(10):685-95
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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