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Cnn1tm1Tkhi
Targeted Allele Detail
Nomenclature
Symbol: Cnn1tm1Tkhi
Name: calponin 1; targeted mutation 1, Katsuhito Takahashi
MGI ID: MGI:2181445
Gene: Cnn1  Location: Chr9:22099221-22109221 bp, + strand  Genetic Position: Chr9, 8.3 cM, cytoband A2-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77112
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA gpt-neo cassette replaced exons 5 through 7, encoding the regulatory binding region, conserved tandem repeats, and a carboxyl-terminal domain specific to the basic Calponin. RT-PCR analysis of homozygous mutant embryos showed an absence of basic transcript in both healthy and healing bone tissue. Western blot analysis confirmed an absence of the basic protein in homozygous mutant mice. (J:77112)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnn1 Mutation:  5 strains or lines available
References
Original:  J:77112 Yoshikawa H, et al., Mice lacking smooth muscle calponin display increased bone formation that is associated with enhancement of bone morphogenetic protein responses. Genes Cells. 1998 Oct;3(10):685-95
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory