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Pla2g4atm1Jvb
Targeted Allele Detail
Nomenclature
Symbol: Pla2g4atm1Jvb
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent); targeted mutation 1, Joseph V Bonventre
MGI ID: MGI:2181427
Synonyms: cPLA2-, cPLA2alpha-, cPLA2-KO, gIVaPLA2null, Pla2g4a-
Gene: Pla2g4a  Location: Chr1:149829618-149961290 bp, - strand  Genetic Position: Chr1, 63.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39681
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of sequences encoding amino acids 187-232 with a PGK-neo-polyA cassette via homologous recombination. Protein product was absent in various organ samples from homozygous mutant animals as determined by Western blot analysis. (J:39681)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pla2g4a Mutation:  2 strains or lines available
References
Original:  J:39681 Bonventre JV, et al., Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature. 1997 Dec 11;390(6660):622-5
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory