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Hfetm1Sly
Targeted Allele Detail
Nomenclature
Symbol: Hfetm1Sly
Name: hemochromatosis; targeted mutation 1, William S Sly
MGI ID: MGI:2181388
Synonyms: HFE-
Gene: Hfe  Location: Chr13:23702034-23710854 bp, - strand  Genetic Position: Chr13, 9.88 cM, cytoband A2-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46169
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hfe Mutation:  11 strains or lines available
Notes
Homozygous mutant mice display transferrin saturation.

References
Original:  J:46169 Zhou XY, et al., HFE gene knockout produces mouse model of hereditary hemochromatosis [see comments]. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2492-7
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory