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Targeted Allele Detail
Symbol: Del(19Poll-Dcpd)1Nmt
Name: deletion, Chr 19, Noboru Motoyama 1
MGI ID: MGI:2181352
Synonyms: Dpcd/Polltm1Nmt, Pol lambda-
Gene: Del(19Poll-Dcpd)1Nmt  Location: unknown  Genetic Position: Chr19, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:75779
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
  Del(19Poll-Dcpd)1Nmt involves 2 genes/genome features (Poll, Dpcd) View all
Mutation detailsThe gene was disrupted by replacement of exons 1-6 with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the translation initiation site, the BRCT motif, and half of the polymerase X domain of Poll. Homozygous mutant animals lack gene expression in testis as determined by Northern blot analysis. Analysis of the genomic region surrounding the Poll gene revealed an uncharacterized gene, named Dpcd, that is predicted to be transcribed from the opposite strand relative to Poll. The deletion of Poll also removes the first exon of Dpcd. (J:75779, J:97294)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(19Poll-Dcpd)1Nmt Mutation:  0 strains or lines available
Phenotypic Similarity to Human Syndrome: Primary Ciliary Dyskinesia in homozygous mice (J:75779)

Original:  J:75779 Kobayashi Y, et al., Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Mol Cell Biol. 2002 Apr;22(8):2769-76
All:  3 reference(s)

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MGI 6.01
The Jackson Laboratory