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Ptprctm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Ptprctm1Mak
Name: protein tyrosine phosphatase, receptor type, C; targeted mutation 1, Tak W Mak
MGI ID: MGI:2181288
Synonyms: cd45-, CD45-exon6-
Gene: Ptprc  Location: Chr1:138062861-138175708 bp, - strand  Genetic Position: Chr1, 60.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:13163
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 6, which is excised in some isoforms, was deleted and replaced with a neomycin selection cassette. Immunofluorescence analysis, using an antibody raised against all isoforms, of cells isolated from homozygous mutant mice showed an absence of encoded protein in B lymphocytes and low levels of expression in peripheral T cells. Flow cytometric analysis of peripheral T cells confirmed that protein containing the region encoded by exon 6 was absent, while protein containing the region encoded by exon 5 was present at low levels. (J:13163)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:  53 strains or lines available
Notes
ES cell line = D3NS.

References
Original:  J:13163 Kishihara K, et al., Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell. 1993 Jul 16;74(1):143-56
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory