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Targeted Allele Detail
Symbol: Serpinf2tm1Hrl
Name: serine (or cysteine) peptidase inhibitor, clade F, member 2; targeted mutation 1, H Roger Lijnen
MGI ID: MGI:2181226
Synonyms: alpha-2-AP-, alpha2-AP-
Gene: Serpinf2  Location: Chr11:75431732-75439591 bp, - strand  Genetic Position: Chr11, 45.89 cM
Germline Transmission:  Earliest citation of germline transmission: J:54047
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaced the entire coding region (exon 2 through the stop codon in exon 10). RT-PCR analaysis of kidney and liver tissue showed an absence of transcript in homozygous mutant mice. Western blot analyses of unactivated and activated plasma confirmed a lack of encoded protein in homozygous mice. Complex formation was undetectable by blotting analysis of plasma incubated with purified plasmin. (J:43244, J:54047)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpinf2 Mutation:  2 strains or lines available
Original:  J:54047 Lijnen HR, et al., Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. Blood. 1999 Apr 1;93(7):2274-81
All:  14 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory