Cry2^tm1Jhjh
Targeted Allele Detail

Summary

• Symbol: Cry2^tm1Jhjh
• Name: cryptochrome circadian regulator 2; targeted mutation 1, Jan H J Hoeijmakers
• MGI ID: MGI:2181206
• Synonyms: cry2-, mCry2-
• Gene: Cry2 Location: Chr2:92233991-92264388 bp, - strand Genetic Position: Chr2, 51.01 cM, cytoband E
• Alliance: Cry2^tm1Jhjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54241
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced coding sequence corresponding to base pairs 397 through 810 in the cDNA sequence. RT-PCR analysis indicated a lack of transcript in homozygous mutant mice. (J:54241)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cry2 Mutation: 40 strains or lines available

References

• Original: J:54241 van der Horst GT, et al., Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms [see comments]. Nature. 1999 Apr 15;398(6728):627-30
• All: 62 reference(s)