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Transgene Detail
Symbol: Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Name: transgene insertion 1, Christophe Benoist
MGI ID: MGI:2181203
Synonyms: BDC2.5, BDC-2.5/N TCR Tg, Tg(TcraBDC2.5)2Doi, Tg(TcrbBDC2.5)2Doi
Transgene: Tg(TcraBDC2.5,TcrbBDC2.5)1Doi  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi expresses 2 genes
Mutation detailsThis transgene results from the coinjection of two constructs derived from diabetogenic T-cell clone BDC2.5. The Tcra construct contains a rearranged Tcra sequence (V alpha J alpha) that begins 20 bp 5' of the ATG site and ends 30 bp 3' of the splice donor sequence of J alpha 17. The 6.5 Tcrb construct contains rearranged Tcrb sequence (V beta D beta J beta) flanked by 2 kb of 5' regulatory sequences and 3.5 kb of 3' DNA containing the unrearranged J beta 1.3 to J beta 1.6 sequences, and precedes a 12 kb sequence containing the C beta 2 region. (J:77007)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:77007 Katz JD, et al., Following a diabetogenic T cell from genesis through pathogenesis. Cell. 1993 Sep 24;74(6):1089-100
All:  121 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory