Gata3^tm1Gsv
Targeted Allele Detail

Summary

• Symbol: Gata3^tm1Gsv
• Name: GATA binding protein 3; targeted mutation 1, Frank Grosveld
• MGI ID: MGI:2181200
• Synonyms: G3-KI, Gata2^nlslacZ, Gata3^-, Gata3^LacZ, Gata3-LacZ, GATA-3^nlslacZ, Gata3^z
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm1Gsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77126
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was disrupted by the insertion of a cassette containing PGK-hygro and NLS-lacZ at the translational start codon. The majority of exon 2 was deleted. (J:77126)

Disease models

Expression

In Mice Carrying this Mutation:	107 assay results
In Structures Affected by this Mutation:	49 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 31 strains or lines available

Notes

ES cell line = AB1 (129S7/SvEvBrd-Hprt⁺) or E14 (129P2/OlaHsd).

References

• Original: J:77126 van Doorninck JH, et al., GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei. J Neurosci. 1999 Jun 15;19(12):RC12
• All: 38 reference(s)