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Crxtm1Clc
Targeted Allele Detail
Nomenclature
Symbol: Crxtm1Clc
Name: cone-rod homeobox; targeted mutation 1, Constance L Cepko
MGI ID: MGI:2181191
Synonyms: Crx-
Gene: Crx  Location: Chr7:15865947-15879968 bp, - strand  Genetic Position: Chr7, 8.6 cM
Outer retina microscopy of Crxtm1Clc/Crxtm1Clc mice

Show the 9 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58796
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe homeodomain coding region containing exon 3 and a portion of exon 4 was replaced by a neomycin selection cassette. RT-PCR analysis showed an absence of transcript in the retinas of homozygous mutant mice. (J:58796)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crx Mutation:  3 strains or lines available
References
Original:  J:58796 Furukawa T, et al., Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet. 1999 Dec;23(4):466-70
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory