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Targeted Allele Detail
Symbol: Bmp4tm3.1Blh
Name: bone morphogenetic protein 4; targeted mutation 3.1, Brigid L Hogan
MGI ID: MGI:2181190
Synonyms: BMP4-fx, Bmp4loxP-lacZ
Gene: Bmp4  Location: Chr14:46383520-46390669 bp, - strand  Genetic Position: Chr14, 23.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:75136
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, Hypomorph, Reporter)
Mutation:    Insertion
Mutation detailsThis hypomorphic allele is a derivative of Bmp4tm3Blh. LoxP sites were inserted flanking exons 3 and 4, and a promoterless lacZ gene was inserted 3' to the loxP insertions. An frt-flanked neomycin selection cassette that was inserted downstream of the lacZ gene was removed by Flpe mediated recombination in the final allele. (J:75136)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:  5 strains or lines available
Original:  J:75136 Kulessa H, et al., Generation of a loxP flanked bmp4(loxP-lacZ) allele marked by conditional lacZ expression. Genesis. 2002 Feb;32(2):66-8
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory