About   Help   FAQ
Cox6a2tm1Djg
Targeted Allele Detail
Nomenclature
Symbol: Cox6a2tm1Djg
Name: cytochrome c oxidase subunit VIa polypeptide 2; targeted mutation 1, Daniel J Garry
MGI ID: MGI:2181189
Synonyms: VIaH-
Gene: Cox6a2  Location: Chr7:128205435-128206387 bp, - strand  Genetic Position: Chr7, 70.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75606
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region of exon 2 encoding 97 amino acids was replaced with a PGK-neo cassette. Northern blot analysis of heart and skeletal muscle showed that homozygous mutant mice lacked transcript. (J:75606)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cox6a2 Mutation:  5 strains or lines available
References
Original:  J:75606 Radford NB, et al., Cardiac dysfunction in mice lacking cytochrome-c oxidase subunit VIaH. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H726-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory