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Bmp4tm3Blh
Targeted Allele Detail
Summary
Symbol: Bmp4tm3Blh
Name: bone morphogenetic protein 4; targeted mutation 3, Brigid L Hogan
MGI ID: MGI:2181188
Synonyms: Bmp4loxP-lacZ-neo
Gene: Bmp4  Location: Chr14:46620982-46628126 bp, - strand  Genetic Position: Chr14, 23.95 cM
Alliance: Bmp4tm3Blh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75136
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph, Reporter)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted flanking exons 3 and 4, and a promoterless lacZ gene was inserted 3' to the loxP insertions. An frt-flanked neomycin selection cassette was also inserted downstream of of the lacZ gene. This allele is reported to behave as a hypomorph. (J:75136)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:  21 strains or lines available
References
Original:  J:75136 Kulessa H, et al., Generation of a loxP flanked bmp4(loxP-lacZ) allele marked by conditional lacZ expression. Genesis. 2002 Feb;32(2):66-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory