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Cntn2tm1Fuka
Targeted Allele Detail
Nomenclature
Symbol: Cntn2tm1Fuka
Name: contactin 2; targeted mutation 1, Fumihiko Fukamauchi
MGI ID: MGI:2181052
Synonyms: TAG-1 (-)
Gene: Cntn2  Location: Chr1:132509425-132543251 bp, - strand  Genetic Position: Chr1, 57.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67556
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe region between exon 2 and 5, encoding the translational start codon through the first Ig-like domain, was replaced by a neomycin selection cassette. Western blot analysis using antibodies raised against the amino and carboxyl terminals showed an absence of encoded protein in homozygous mutant mice. (J:67556)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 28 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cntn2 Mutation:  5 strains or lines available
References
Original:  J:67556 Fukamauchi F, et al., TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus. Biochem Biophys Res Commun. 2001 Feb 16;281(1):220-6
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory