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Cntftm1Gdy
Targeted Allele Detail
Nomenclature
Symbol: Cntftm1Gdy
Name: ciliary neurotrophic factor; targeted mutation 1, George D Yancopoulos
MGI ID: MGI:2181048
Synonyms: CNTF-
Gene: Cntf  Location: Chr19:12763660-12765632 bp, - strand  Genetic Position: Chr19, 8.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29357
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exons 1 and 2. Western blot analysis showed an absence of encdoded protein in sciatic nerve extracts from homozygous mutant mice. (J:29357)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cntf Mutation:  3 strains or lines available
References
Original:  J:29357 DeChiara TM, et al., Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 1995 Oct 20;83(2):313-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory