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Dclre1atm1Roka
Targeted Allele Detail
Nomenclature
Symbol: Dclre1atm1Roka
Name: DNA cross-link repair 1A; targeted mutation 1, Roland Kanaar
MGI ID: MGI:2180947
Synonyms: SNM1 -
Gene: Dclre1a  Location: Chr19:56529167-56548222 bp, - strand  Genetic Position: Chr19, 51.89 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62832
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was incorporated to delete part of intron 3 and 25 bp of exon 4. This targeting event resulted in the removal of the C-terminal 2876 amino acids which contain most of the conserved motifs. (J:62832)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dclre1a Mutation:  17 strains or lines available
References
Original:  J:62832 Dronkert ML, et al., Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C. Mol Cell Biol. 2000 Jul;20(13):4553-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory