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Lrp1tm2Her
Targeted Allele Detail
Nomenclature
Symbol: Lrp1tm2Her
Name: low density lipoprotein receptor-related protein 1; targeted mutation 2, Joachim Herz
MGI ID: MGI:2180880
Synonyms: LRPflox, lrplox
Gene: Lrp1  Location: Chr10:127538161-127621148 bp, - strand  Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76281
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP-flanked PGK-neomycin selection cassette was inserted 240 bp upstream of the transcription initiation site, and a third loxP site was inserted 3' to exon 1 in intron 2. (J:76281)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp1 Mutation:  27 strains or lines available
References
Original:  J:76281 Rohlmann A, et al., Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nat Biotechnol. 1996 Nov;14(11):1562-5
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory