About   Help   FAQ
Lrp1tm2Her
Targeted Allele Detail
Summary
Symbol: Lrp1tm2Her
Name: low density lipoprotein receptor-related protein 1; targeted mutation 2, Joachim Herz
MGI ID: MGI:2180880
Synonyms: LRPflox, lrplox
Gene: Lrp1  Location: Chr10:127374030-127457017 bp, - strand  Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
Alliance: Lrp1tm2Her page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76281
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP-flanked PGK-neomycin selection cassette was inserted 240 bp upstream of the transcription initiation site, and a third loxP site was inserted 3' to exon 1 in intron 2. (J:76281)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp1 Mutation:  134 strains or lines available
References
Original:  J:76281 Rohlmann A, et al., Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nat Biotechnol. 1996 Nov;14(11):1562-5
All:  108 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/26/2022
MGI 6.22
The Jackson Laboratory