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Itga4tm1Jty
Targeted Allele Detail
Nomenclature
Symbol: Itga4tm1Jty
Name: integrin alpha 4; targeted mutation 1, Joy T Yang
MGI ID: MGI:2180843
Synonyms: alpha4KI-lacZ
Gene: Itga4  Location: Chr2:79255426-79333114 bp, + strand  Genetic Position: Chr2, 47.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76747
Parent Cell Line:  MC3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details91 bp of exon 1 was replaced with a PGK-neo-lacZ reporter cassette via homologous recombination resulting in the deletion of 22 of 39 signal peptide residues and 8 residues from the amino terminus of the mature protein. Homozygous mutant embryos were identified by PCR analysis. (J:76747)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga4 Mutation:  39 strains or lines available
References
Original:  J:76747 Sengbusch JK, et al., Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol. 2002 May 27;157(5):873-82
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory