About   Help   FAQ
MaoaTg(H2-K1-Ifnb1)8Seif
Transgenic Allele Detail
Nomenclature
Symbol: MaoaTg(H2-K1-Ifnb1)8Seif
Name: monoamine oxidase A; transgene insertion 8, Isabelle Seif
MGI ID: MGI:2180818
Synonyms: MAO-A knockout, MAOA-KO, MaoaTg(H2-IFNB)8Seif, Tg8
Gene: Maoa  Location: ChrX:16619698-16687818 bp, + strand  Genetic Position: ChrX, 11.78 cM, cytoband A2
Transgene
origin
Strain of Origin:  C3H/HeOuJ
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsRandom integration of a transgene for IFN beta expressed under the control of a truncated H2-K1 promoter resulted in deletion of a 17 kb region encompassing exons 2 and 3 of the Maoa gene. Enzyme activity was absent in brain and spleen samples from mutant animals. (J:26232)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Maoa Mutation:  7 strains or lines available
References
Original:  J:26232 Cases O, et al., Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA [see comments]. Science. 1995 Jun 23;268(5218):1763-6
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/17/2015
MGI 5.21
The Jackson Laboratory