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S1pr2tm1Ajml
Targeted Allele Detail
Nomenclature
Symbol: S1pr2tm1Ajml
Name: sphingosine-1-phosphate receptor 2; targeted mutation 1, A John MacLennan
MGI ID: MGI:2180817
Synonyms: H218-, S1P2-
Gene: S1pr2  Location: Chr9:20965952-20976793 bp, - strand  Genetic Position: Chr9, 7.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73957
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of an IRES Beta-galactosidase/MC1-neomycin resistance cassette replaced the entire open reading frame including the start codon. RT-PCR studies did not detect transcript in embryonic, 4-week, or adult brain tissue from homozygous mutant mice. (J:73957)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any S1pr2 Mutation:  34 strains or lines available
Notes
All animals used in J:73957 were derived from F1, F2 or F3 heterozygous crosses.
References
Original:  J:73957 MacLennan AJ, et al., An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability. Eur J Neurosci. 2001 Jul;14(2):203-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory