Nodal^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Nodal^tm1Rob
• Name: nodal growth differentiation factor; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:2180793
• Synonyms: Nodal^-, nodal-KO, nodal^lacZ, nodal.lacZ, Nodal^tm1Robv
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32935
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 400 bp segment from the second exon was replaced with an IRES-lacZ and neomycin gene fusion cassette. Beta-galactosidase was expressed from this allele under the control of the endogenous promoter. (J:32935, J:48467)

Disease models

Expression

In Mice Carrying this Mutation:	158 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 41 strains or lines available

References

• Original: J:32935 Collignon J, et al., Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature. 1996 May 9;381(6578):155-8
• All: 58 reference(s)