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Nodaltm1Rob
Targeted Allele Detail
Nomenclature
Symbol: Nodaltm1Rob
Name: nodal; targeted mutation 1, Elizabeth J Robertson
MGI ID: MGI:2180793
Synonyms: Nodal-, nodal-KO, nodallacZ, nodal.lacZ
Gene: Nodal  Location: Chr10:61417972-61425338 bp, + strand  Genetic Position: Chr10, 32.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32935
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  17 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Holoprosencephaly in mice homozygous for Chrdtm1Emdr and heterozygous for Nodaltm1Rob in J:161524

References
Original:  J:32935 Collignon J, et al., Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature. 1996 May 9;381(6578):155-8
All:  51 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory