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Targeted Allele Detail
Symbol: Comptm1Aol
Name: cartilage oligomeric matrix protein; targeted mutation 1, Ake Oldberg
MGI ID: MGI:2180787
Synonyms: COMP-null, TSP5 KO
Gene: Comp  Location: Chr8:70373548-70382065 bp, + strand  Genetic Position: Chr8, 34.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:76781
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette via homologous recombination into sequences encoding the first type 3 repeat. Northern blot, RT-PCR analysis, and Western blot of RNA and proteins extracted from the processus xiphoideus of homozygous mutant mice verified the absence of gene expression. (J:76781)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Comp Mutation:  1 strain or line available
Original:  J:76781 Svensson L, et al., Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol. 2002 Jun;22(12):4366-71
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory