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Targeted Allele Detail
Symbol: Cdh4tm1Semb
Name: cadherin 4; targeted mutation 1, Henrik Semb
MGI ID: MGI:2180782
Synonyms: R-cadherin-
Gene: Cdh4  Location: Chr2:179442431-179899373 bp, + strand  Genetic Position: Chr2, 101.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:74658
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin selection cassette replaced exon 1 and exon 2. An absence of transcript in kidneys isolated from homozygous mutant embryos was determined via Northern blot analysis using probes for the 5' terminal, middle, and 3' terminal of the endogenous cDNA. Immunoblotting of brain extracts showed a lack of protein. (J:74658)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh4 Mutation:  24 strains or lines available
Original:  J:74658 Dahl U, et al., Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol. 2002 Mar;22(5):1474-87
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory