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Targeted Allele Detail
Symbol: Cd59atm1Bpm
Name: CD59a antigen; targeted mutation 1, B Paul Morgan
MGI ID: MGI:2180771
Synonyms: CD59-, Cd59a-, mCd59a-
Gene: Cd59a  Location: Chr2:104095801-104115354 bp, + strand  Genetic Position: Chr2, 54.53 cM, cytoband E2-E4
Germline Transmission:  Earliest citation of germline transmission: J:70419
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was inserted to replace exon 3, which encodes the majority of the protein. FACS analysis showed an absence of protein expression on the surface of erythrocytes, leukocytes, and platelets isolated from homozygous mutant mice. The lack of protein expression was confirmed by immunhistochemical analysis in a variety of tissues. (J:70419)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd59a Mutation:  10 strains or lines available
Original:  J:70419 Holt DS, et al., Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria. Blood. 2001 Jul 15;98(2):442-9
All:  24 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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