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Cd48tm1Rsr
Targeted Allele Detail
Nomenclature
Symbol: Cd48tm1Rsr
Name: CD48 antigen; targeted mutation 1, Hans Reiser
MGI ID: MGI:2180770
Synonyms: CD48-
Gene: Cd48  Location: Chr1:171682009-171705258 bp, + strand  Genetic Position: Chr1, 79.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53718
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced the exon encoding the immunoglobulin-V-like domain, which forms a binding site for the Cd2 antigen. Thymocytes and splenocytes isolated from homozygous mutant mice were found to lack surface expression of the endogenous protien. (J:53718)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd48 Mutation:  13 strains or lines available
References
Original:  J:53718 Gonzalez-Cabrero J, et al., CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1019-23
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory