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Cd34tm1Lal
Targeted Allele Detail
Nomenclature
Symbol: Cd34tm1Lal
Name: CD34 antigen; targeted mutation 1, L A Lasky
MGI ID: MGI:2180758
Gene: Cd34  Location: Chr1:194938819-194961279 bp, + strand  Genetic Position: Chr1, 98.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30621
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into the exon encoding the signal sequence, disrupting the reading frame downstream. Homozygosity in ES cells was achieved by gene conversion. FACS analysis of homozygous mutant ES cells showed an absence of protein surface expression. The absence of encoded protein mice derived from these clones was determined via immunohistochemical analysis. (J:30621)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd34 Mutation:  3 strains or lines available
References
Original:  J:30621 Cheng J, et al., Hematopoietic defects in mice lacking the sialomucin CD34. Blood. 1996 Jan 15;87(2):479-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory