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Targeted Allele Detail
Symbol: Maobtm1Shih
Name: monoamine oxidase B; targeted mutation 1, Jean C Shih
MGI ID: MGI:2180752
Synonyms: MAOB KO
Gene: Maob  Location: ChrX:16575521-16683605 bp, - strand  Genetic Position: ChrX, 11.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:43648
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a neo cassette into exon 6 via homologous recombination resulting in a premature stop codon and protein truncation. Enzyme assays of brain and liver extracts from mutant mice demonstrated background levels of enzyme activity. Western blot and immunohistochemical analyses failed to detect protein product. (J:43648)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Maob Mutation:  11 strains or lines available
ES cell line = CCE (129S/SvEv-Gpi1c) or J1 (129S4/SvJae).
Original:  J:43648 Grimsby J, et al., Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997 Oct;17(2):206-10
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory